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　　报告题目：Methylation of arginine decodes the regulation of protein functions induced by PKB/Akt signaling

　　报告人：Professor Akiyoshi Fukamizu 

　　Director, Center for Tsukuba Advanced Research Alliance,

　　University of Tsukuba

　　时间：2010年3月16日(星期二)上午10:30

　　地点：医学部逸夫教学楼409

　　主持人：朱卫国教授

　　                             报告人简介：

　　Awards:

　　1993   Young Investigator’s Award from Japan Vascular Disease Research Foundation.

　　1993   Nikkei BP Award (Medical Science Aspect) from Nikkei Business Publication.

　　1995 Jokichi Takamine Young Investigator’s Award from the Japanese Society of Cardiovascular and Endocrinological Metabolism.

　　1996   Young Investigator’s Award from the Japanese Society of Biochemistry.

　　Publication：

1．        Yamagata K, Daitoku H, Takahashi Y, Namiki K, Hisatake K, Kako K, Mukai H, Kasuya Y, Fukamizu A. Arginine methylation of FOXO transcription factors inhibitstheir phosphorylation by Akt. Mol Cell. 2008 Oct 24;32(2):221-31.

2．        Matsuzaki H, Daitoku H, Hatta M, Aoyama H, Yoshimochi K, Fukamizu A. Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation. Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11278-83. Epub 2005 Aug 2.

3．        Tanimoto K, Shimotsuma M, Matsuzaki H, Omori A, Bungert J, Engel JD, Fukamizu A. Genomic imprinting recapitulated in the human beta-globin locus. Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10250-5. Epub 2005 Jul 8.

4．        Zou Y, Akazawa H, Qin Y, Sano M, Takano H, Minamino T, Makita N, Iwanaga K Zhu W, Kudoh S, Toko H, Tamura K, Kihara M, Nagai T, Fukamizu A, Umemura S, Iiri  T, Fujita T, Komuro I. Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II. Nat Cell Biol. 2004 Jun;6(6):499-506.  Epub 2004 May 16.

5．        Ide T, Shimano H, Yahagi N, Matsuzaka T, Nakakuki M, Yamamoto T, Nakagawa Y,  Takahashi A, Suzuki H, Sone H, Toyoshima H, Fukamizu A, Yamada N. SREBPs suppress IRS-2-mediated insulin signalling in the liver. Nat Cell Biol. 2004 Apr;6(4):351-7. Epub 2004 Mar 14.