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报告题目：From BRCA1 to Sirtuins: Cancer, Metabolism and Aging

报 告 人：Professor Chuxia Deng 

Chief, Mammalian Genetics Section
GDDB, NIDDK, National Institutes of Health

时    间： 2011年5月10日 (星期二) 下午17:00

地    点：医学部生化楼三层中厅

主 持 人： 朱卫国教授

 

报告人简介：

Dr. Chuxia Deng is a famous scientist with a wide range of scientific interests and accomplishments in mammalian development and animal model systems. He received M.S. from Chinese Academy of Sciences in 1984, and Ph.D. from University of Utah in 1992 under the supervision of Prof. Mario R. Capecchi(2007 Nobel Prize). Then he worked as a postdoctoral fellow with Prof. Philip Leder for three years in the Genetics Department, Harvard Medical School. Dr.Deng became an investigator in Laboratory of Biochemistry and Metabolism, National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) of National Institutes of Health in 1995. He currently works as Senior Investigator and Chief of Mammalian Genetics Section, Genetics of Development and Disease Branch of NIDDK,NIH.His current researches focus on FGF/FGF receptor,TGFb/SMADs signaling, and Brca1 tumor suppressor gene.

Dr. Deng has received numerous honors throughout his distinguished career, including the NIH-APAO Outstanding Achievement Award (2000), Outstanding Oversea Scholar from National Science Foundation of China (2002), and NIDDK "You Make A Difference Award" (2005). He currently serves as an Editor-in-Chief in the International Journal of Biological Sciences.

Selected Publications:

1.Wang RH, Zheng Y Finkel T, Deng CX Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis. Mol Cell(32): 11-20, 2008.

2.Wang RH, Ried T, Deng CX Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell(14): 312-23, 2008. 

3.Shukla V, Deng CX RNA interference and inhibition of MEK-ERK signaling preventabnormal skeletal phenotypes in a mouse model of craniosynostosis. Nat Genet, 2007.