讲演人：Luonan Chen (陈洛南)

  Executive Director, Key Laboratory of Systems Biology, 
         Executive Director, SIBS-Novo Nordisk Translational Research Centre for
         PreDiabetes, 
         Shanghai Institutes for Biological Sciences, 
         Chinese Academy of Sciences, China;
         Invited Professor, Computational Biology Research Center,
         National Institute of Advanced Industrial Science and Technology, Japan.
   

时间：                                           7                 月                 6                 日中午             11:30-12:30.      

地点：北京大学医学部生理楼三楼会议室 （三层中厅）

欢迎参加！

                    主办：生理学与病理生理学系、生物医学信息学系      

报告摘要：

This talk will describe a general framework to infer genetic networks at three different levels, i.e. gene regulatory network, 

transcriptional regulatory network and TF activity network, by combining multiple high-throuphput datasets with different conditions. 

The proposed methodologies are based on mathemtical programming and decomposition techniques. The computational methods 

theoretically ensure the derivation of the most consistent network structure with respect to all of the datasets, thereby not only 

significantly alleviating the problem of data scarcity but also remarkably improving the prediction reliability.We tested our approaches 

using both simulated data and experimental data in yeast and other organisms. The result demonstrates the effectiveness in terms of 

predicting accuracy and power. The software is available from my website or upon request.                 

Related References:                 

[1]. L.Chen, RS.Wang, and XS.Zhang. Biomolecular Network: Methods and Applications in Systems Biology, John Wiley & Sons, 2009.                  

[2]. L.Chen, RQ.Wang, C.Li, and K. Aihara. Modeling Biomolecular Networks in Cells: Structures and Dynamics. Springer, 2010.                 

                             报告人简介： 

Luonan Chen received the M.E. and Ph.D. degrees in the electrical engineering, from Tohoku University, Sendai, Japan , in 1988 and 1991, respectively. From 1997, he was an associate professor of the Osaka Sangyo University, Osaka, Japan , and then a full Professor. Since 2010, he has been a professor at Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. He was the founding director of Institute of Systems Biology, Shanghai University, and from 2009 he has also been an invited professor in Computational Biology Research Center, National Institute of Advanced Industrial Science and Technology, Japan . He serves as Chair of Technical Committee of Systems Biology at IEEE SMC Society. His fields of interest are systems biology, bioinformatics, and nonlinear dynamics. He serves as associate editor or editorial board member for many systems biology related journals, e.g. BMC Systems Biology, IEEE/ACM Trans. On Computational Biology and Bioinformatics, IET Systems Biology, Mathematical Biosciences, Neural Processing Letters, Int. J. of Systems and Synthetic Biology, and J. of Systems Science and Complexity. In recent five years, he published over 100 journal papers in the area of systems biology.