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报告题目：The regulation of stem cell self-renewal

报告人：Sean J. Morrison, PhD

Director of the Children’s Research

Institute and the Mary McDermott Cook-

Chair in Pediatric Genetics at the

University of Texas Southwestern Medical Center

时间： 2012年2月20日 (星期一) 上午10：00

地点：逸夫楼509教室

主持人： 尹玉新教授

                                                         报告人简介：

The Morrison laboratory is investigating the mechanisms that regulate stem cell function in the nervous and hematopoietic systems and the ways in which these mechanisms are hijacked by cancer cells to enable neoplastic proliferation and metastasis. He is particularly interested in the mechanisms that regulate stem cell self-renewal, stem cell aging, and the role these mechanisms play in cancer. He has discovered a number of critical mechanisms that distinguish stem cell self-renewal from the proliferation of restricted progenitors. They have shown that stem cell self-renewal is regulated by networks of proto-oncogenes and tumor suppressors and that the balance between proto-oncogenic and tumor suppressor signals changes with age. The Morrison laboratory has further shown that many tumor cells are capable of driving disease growth and progression while other cancers are driven by minority subpopulations of cancer cells that adopt “stem cell” characteristics. These insights into the cellular and molecular mechanisms of self-renewal have suggested new approaches for promoting normal tissue regeneration and cancer treatment.

 

Dr. Morrison received his Ph.D. from Stanford University in 1996 and he has been the Director of the Center for Stem Cell Biology at the University of Michigan since 1999. Recently, Dr. Morrison moved to the University of Texas Southwestern Medical Center where he is the founding Director of the new Children’s Research Institute. Dr. Morrison was a Searle Scholar (2000-2003), received the Presidential Early Career Award for Scientists and Engineers (2003), the International Society for Hematology and Stem Cell’s McCulloch and Till Award (2007) the American Association of Anatomists Harland Mossman Award (2008), and a MERIT Award from the National Institute on Aging (2009).