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报告题目：Signaling by WW domain proteins in Hippo-YAP pathway, Golabi-Ito-Hall syndrome and Ebola virus egress

报告人：Marius Sudol, Ph.D.

             Joint Senior Principal Investigator,

             Institute of Molecular and Cell Biology (IMCB) A*STAR, Singapore

             Co-Principal Investigator, Mechanobiology Institute, Singapore

             Associate Professor, Department of Physiology,

             National University of Singapore, Singapore

时间：2018年5月31日（星期四） 上午10:00-11:30

地点：医学部会议中心206会议室

主持人：吴聪颖

报告人简介：

Marius Sudol is an Associate Professor in the Department of Physiology at the National University of Singapore with a joint appointment at the Mechanobiology Institute. His attraction to the academia in Singapore was the pioneering work of Professor Michael Sheetz in the field of Mechanobiology and a discovery that a cancer-signaling pathway that his lab investigated, namely Hippo-YAP pathway, turned out to be tightly regulated by mechanical cues. Dr. Sudol was also instrumental in the delineation and characterization of one of the smallest protein-protein interaction modules, the WW domain. His work implicated the WW domain in several human diseases, including Liddle syndrome of hypertension and Golabi-Ito-Hall syndrome of intellectual disability. He earned a Ph.D. degree at The Rockefeller University in New York and stayed at his Alma Mater as a postdoctoral fellow and Assistant Professor. Afterword, he was appointed to a rank of Associate Professor at the Mount Sinai School of Medicine in New York City. In 2014 he moved to Singapore. Dr. Sudol has published over 170 research articles and serves on editorial boards of several journals including “Science Signaling”, “Oncogene” and “Journal of Biological Chemistry”.