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生理与病理生理学系学术活动

生理与病理生理学系及糖尿病中心学术活动

题目:1. 水杨酸钠抑制TNF-alpha刺激的脂肪分解

            2.  地塞米松刺激脂肪分解及其机制研究

讲演人:徐国恒    教授

                北京大学医学部生理与病理生理学系

时间:2007-11-23(Friday),11:30am

地点:生理楼三层会议室

 

徐国恒教授,生理与病生理学系肥胖与代谢研究室负责人,主要研究方向为:脂肪分解和脂肪酸运动的分子调控机制以及肥胖、胰岛素抵抗、泡沫细胞形成的细胞生物学机制。2004年入选教育部新世纪优秀人才支持计划,获得专项资助,现承担多项国家级课题,近两年部分性代表论文包括: Zu L, Jiang H, He J, Xu C, Pu S, Liu M, Xu G. Salicylate Blocks Lipolytic Actions of Tumor Necrosis Factor-TNF-{alpha} in Primary Rat Adipocytes. Mol Pharmacol. 2007 Oct 2; [Epub ahead of print] Jiang H, He J, Pu S, Tang C, Xu G. Heat shock protein 70 is translocated to lipid droplets in rat adipocytes upon heat stimulation. Biochim Biophys Acta. 2007 Jan;1771(1):66-74. Ren T, He J, Jiang H, Zu L, Pu S, Guo X, Xu G. Metformin reduces lipolysis in primary rat adipocytes stimulated by tumor necrosis factor-alpha or isoproterenol. J Mol Endocrinol. 2006 Aug;37(1):175-83. He J, Jiang H, Tansey JT, Tang C, Pu S, Xu G. Calyculin and okadaic acid promote perilipin phosphorylation and increase lipolysis in primary rat adipocytes. Biochim Biophys Acta. 2006 Feb;1761(2):247-55. Xu G, Sztalryd C, Lu X, Tansey JT, Gan J, Dorward H, Kimmel AR, Londos C.  Post-translational regulation of adipose differentiation-related protein by the ubiquitin/proteasome pathway. J Biol Chem. 2005 Dec 30;280(52):42841-7.

 

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