报告人：云彩虹

        Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115 USA

报告题目：Fighting Lung Cancer Caused by Mutational EGFR Activation: A Legend of Anti-EGFR Inhibitors      

报告地点：生化楼3层中厅      

报告时间：                              2010                 年                 5                 月                 17                 日下午                 2                 点             

                                           主办：bat365官网登录入口 生物物理学系 

                             欢迎参加。 

报告人简历      

2004 –          Postdoctoral Research Associate，Dana-Farber Cancer Institute & Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115 USA

1998 - 2004      Ph.D. Student，Division of Structural Biology, National Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101 China

PUBLICATIONS

1.      Eck MJ, Yun CH (2010). Structural and mechanistic underpinnings of the differential drug

sensitivity of EGFR mutations in non-small cell lung cancer. Biochim Biophys Acta, 1804(3) 559-566. (review)

2.      Zhou W*, Ercan D*, Chen L*, Yun CH*, Li D, Capelletti M, Cortot AB, Chirieac L, Iacob RE,

Padera R, Engen JR, Wong KK, Eck MJ, Gray NS, J?nne PA (2009), Novel mutant-selective EGFR kinase inhibitors against EGFR T 790M , Nature, 462(7276):1070-1074. (*These authors contributed equally to this work.)

3. Yun CH, Mengwasser KE, Toms AV, Woo MS, Greulich H, Wong KK, Meyerson M, and Eck MJ (2008). The T 790M gatekeeper mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP.  Proc. Natl. Acad. Sci. USA, 105(6):2070-2075.

4. Yun CH, Boggon TJ, Li Y, Woo MS, Greulich H, Meyerson M, and Eck MJ (2007). Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity. Cancer Cell, 11(3):217-227.

5. Blair JA, Rauh D, Kung C, Yun CH, Fan QW, Rode H, Zhang C, Eck MJ, Weiss WA and Shokat KM (2007). Structure-guided development of affinity probes for tyrosine kinases using chemical genetics. Nat. Chem. Biol., 3(4):229-238.